Both Norovirus and Clostridium difficile are fecal-oral transmitted. The primary manner to prevent transmission is handwashing with soap and water. In addition, the environment has been implicated in transmission of both Norovirus and Clostridium difficile through contaminated environmental surfaces. The US Centers for Disease Control and Prevention recommends the use of an EPA-registered disinfectant with an efficacy claim against Clostridium difficile or Norovirus for cleaning and disinfection of environmental surfaces. Finally, clinicians should deploy a comprehensive antibiotic stewardship campaign to ensure that antibiotics are judiciously utilized since overuse of antibiotics are a major causative agent of Clostridium difficile.
Source: Centers for Disease Control and Prevention Guidelines for Disinfection and Sterilization in Healthcare Facilities, 2008.