Recently, the US Food and Drug Administration released updated guidance that states Chlorhexidine gluconate based antiseptics can be used “with care” in infants under two months of age. As with any skin antiseptic, the clinician should carefully evaluate the patient and their skin for maturity prior to using any antiseptics on the skin. The National Association of Neonatal Nurses (NANN) also have specific recommendations for the use of antiseptics on neonatal skin. It is critical to allow the skin antiseptic to completely air dry prior to dressing application. It is not necessary to remove the antiseptic once applied.
Source: Food and Drug Administration